Blar i forfatter "Simon-Santamaria, Jaione"

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    • Autocrine Prostaglandin E-2 Signaling Promotes Tumor Cell Survival and Proliferation in Childhood Neuroblastoma 

      Rasmuson, Agnes; Kock, Anna; Fuskevåg, Ole-Martin; Kruspig, Björn; Simon-Santamaria, Jaione; Gogvadze, Vladimir; Johnsen, John Inge; Kogner, Per; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Prostaglandin E2 (PGE2) is an important mediator in tumor-promoting inflammation. High expression of cyclooxygenase-2 (COX-2) has been detected in the embryonic childhood tumor neuroblastoma, and treatment with COX inhibitors significantly reduces tumor growth. Here, we have investigated the significance of a high COX-2 expression in neuroblastoma by analysis of PGE2 production, the expression pattern ...

    • Autofluorescence in freshly isolated adult human liver sinusoidal cells 

      Larsen, Anett Kristin; Simon-Santamaria, Jaione; Elvevold, Kjetil; Ericzon, Bo Gøran; Mortensen, Kim Erlend; McCourt, Peter Anthony; Smedsrød, Bård; Sørensen, Karen Kristine (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-13)
      Autofluorescent granules of various sizes were observed in primary human liver endothelial cells (LSECs) upon laser irradiation using a wide range of wavelengths. Autofluorescence was detected in LAMP-1 positive vesicles, suggesting lysosomal location. Confocal imaging of freshly prepared cultures and imaging flow cytometry of non-cultured cells revealed fluorescence in all channels used. Treatment ...

    • Changes in the proteome and secretome of rat liver sinusoidal endothelial cells during early primary culture and effects of dexamethasone 

      Li, Ruomei; Bhandari, Sabin; Martinez-Zubiaurre, Inigo; Bruun, Jack-Ansgar; Urbarova, Ilona Halva; Smedsrød, Bård; Simon-Santamaria, Jaione; Sørensen, Karen Kristine (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-02)
      Introduction<p> <p>Liver sinusoidal endothelial cells (LSECs) are specialized fenestrated scavenger endothelial cells involved in the elimination of modified plasma proteins and tissue turnover waste macromolecules from blood. LSECs also participate in liver immune responses. A challenge when studying LSEC biology is the rapid loss of the in vivo phenotype in culture. In this study, we have ...

    • Dose- and time-dependent effects of triethylene glycol dimethacrylate on the proteome of human THP-1 monocytes 

      Nilsen, Bo Wold; Simon-Santamaria, Jaione; Ørtengren, Ulf Thore; Jensen, Einar; Bruun, Jack-Ansgar; Michelsen, Vibeke Barman; Sørensen, Karen Kristine (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-27)
      Triethylene glycol dimethacrylate (TEGDMA) is commonly used in polymer resinbased dental materials. This study investigated the molecular mechanisms of TEGDMA toxicity by identifying its time- and dose-dependent effects on the proteome of human THP-1 monocytes. The effects of different concentrations (0.07– 5 mM) and exposure times (0–72 h) of TEGDMA on cell viability, proliferation, and morphology ...

    • Efficient uptake of blood-borne BK and JC polyomavirus-like particles in endothelial cells of liver sinusoids and renal vasa recta 

      Simon-Santamaria, Jaione; Rinaldo, Christine Hanssen; Kardas, Piotr; Li, Ruomei; Malovic, Ivana; Elvevold, Kjetil H.; McCourt, Peter Anthony; Smedsrød, Bård; Hirsch, Hans H.; Sørensen, Karen Kristine (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-06)

    • Highly oxidized albumin is cleared by liver sinusoidal endothelial cells via the receptors stabilin-1 and -2 

      Holte, Christopher Florian; Szafranska, Karolina Joanna; Kruse, Larissa Dorothea; Simon-Santamaria, Jaione; Li, Ruomei; Svistounov, Dmitri; McCourt, Peter Anthony (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-05)
      Oxidized albumin (oxHSA) is elevated in several pathological conditions, such as decompensated cirrhosis, acute on chronic liver failure and liver mediated renal failure. Patient derived oxidized albumin was previously shown to be an infammatory mediator, and in normal serum levels of oxHSA are low. The removal from circulation of oxidized albumins is therefore likely required for maintenance of ...

    • Transcriptome and proteome profiling reveal complementary scavenger and immune features of rat liver sinusoidal endothelial cells and liver macrophages 

      Bhandari, Sabin; Li, Ruomei; Simon-Santamaria, Jaione; McCourt, Peter Anthony; Johansen, Steinar Daae; Smedsrød, Bård; Martinez, Inigo Zubiavrre; Sørensen, Karen Kristine (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-27)
      <i>Background</i> - Liver sinusoidal endothelial cells (LSECs) and Kupffer cells (KCs; liver resident macrophages) form the body’s most effective scavenger cell system for the removal of harmful blood-borne substances, ranging from modified self-proteins to pathogens and xenobiotics. Controversies in the literature regarding the LSEC phenotype pose a challenge when determining distinct functionalities ...